After the challenge (hrs)

Patients n = 23

Before the challenge

1

6

12

24

36

48

56

72

Leukocytes^□

DYAR

8.9 ± 0.5

10.1 ± 0.8

10.5 ± 0.4

11.9 ± 0.9⁺

12.7 ± 0.5^*

13.5 ± 0.6^*

12.9 ± 0.7^*

11.6 ± 0.3⁺

10.0 ± 0.5

PBS

8.3 ± 0.4

7.9 ± 0.7

7.8 ± 1.0

8.2 ± 0.9

7.4 ± 0.5

8.4 ± 1.0

8.0 ± 0.6

7.9 ± 0.5

8.1 ± 0.4

Eosinophils^□□

DYAR

293 ± 27

332 ± 35

318 ± 24

343 ± 30

281 ± 29

272 ± 27

301 ± 30

247 ± 25

288 ± 34

PBS

285 ± 21

309 ± 45

293 ± 26

268 ± 22

311 ± 47

256 ± 22

295 ± 29

287 ± 34

276 ± 23

Neutrophils^□□□

DYAR

6.4 ± 0.3

6.7 ± 0.9

6.6 ± 0.5

10.1 ± 0.8^*

10.5 ± 0.7^*

9.4 ± 1.1^*

8.7 ± 0.4^*

7.1 ± 0.3

6.2 ± 0.6

PBS

5.9 ± 1.1

6.0 ± 0.8

6.9 ± 0.4

6.1 ± 0.5

6.5 ± 0.9

7.1 ± 0.4

6.8 ± 0.7

6.2 ± 0.5

6.4 ± 0.3

Thrombocytes^○

DYAR

343 ± 41

320 ± 25

329 ± 23

347 ± 40

368 ± 34

415 ± 53

386 ± 31

319 ± 27

333 ± 29

PBS

298 ± 17

336 ± 37

323 ± 25

299 ± 16

354 ± 27

318 ± 21

349 ± 38

301 ± 20

285 ± 26

Differential count^○○

Eosinophils

DYAR

0.41

0.52

0.40

0.58

0.39

0.53

0.36

0.38

0.29

PBS

0.34

0.37

0.39

0.34

0.26

0.43

0.25

0.26

0.19

Neutrophils

DYAR

6.4

6.8

6.5

8.5^*

9.4^*

9.8^*

9.1^*

8.9^*

7.0

PBS

6.0

6.3

6.7

5.5

6.6

6.9

5.8

7.1

5.9

Basophils

DYAR

0.06

0.09

0.10

0.05

0.10

0.05

0.09

0.06

0.15

PBS

0.07

0.03

0.05

0.10

0.08

0.09

0.04

0.09

0.05

Monocytes

DYAR

0.55

0.6

1. 0

1.9^*

1.8^*

1.7^*

1.1⁺

0.5

0.6

PBS

0.35

0.2

0.7

0.6

0.5

0.35

0.45

0.25

0.5

Lymphocytes

DYAR

2.8

3.1

3.8⁺

3.5

4.7^*

4.8^*

3.9⁺

2.5

2.4

PBS

2.4

2.2

3.4

3.7

2.9

3.0

2.6

2.3

2.5

Th₁/Th₂ ratio (%)^∆

DYAR

8.0 ± 1.5

8.6 ± 2.1

9.9 ± 3.0⁺

14.7 ± 4.0^*

16.2 ± 3.5^*

17.1 ± 3.0^*

16.4 ± 3.4^*

15.6 ± 4.5^*

9.1 ± 2.2

PBS

7.3 ± 3.1

8.2 ± 3.0

9.4 ± 2.1

7.5 ± 3.4

8.8 ± 3.7

9.0 ± 4.1

9.3 ± 3.1

8.9 ± 4.2

7.6 ± 2.6

IFN-γ (pg/mL)

DYAR

2.4 ± 0.5

2.7 ± 1.0

4.9 ± 0.4⁺

9.2 ± 1.7^*

9.0 ± 3.1^*

8.8 ± 3.2^*

7.1 ± 1.3^*

3.1 ± 1.0

2.9 ± 0.3

PBS

2.1 ± 0.2

1.9 ± 0.8

2.2 ± 0.6

1.9 ± 0.8

2.4 ± 0.5

2.2 ± 1.0

2.5 ± 1.0

2.4 ± 0.5

2.3 ± 0.2

IL-4 (pg/mL)

DYAR

3.0 ± 0.1

3.2 ± 0.1

3.5 ± 0.4

3.7 ± 0.6

3.2 ± 0.4

3.4 ± 0.3

3.5 ± 0.5

3.3 ± 0.5

3.5 ± 0.4

PBS

3.1 ± 0.2

3.0 ± 0.2

3.3 ± 0.1

3.4 ± 0.5

3.5 ± 0.2

3.0 ± 0.2

3.4 ± 0.7

3.5 ± 0.6

3.2 ± 0.1